Synthetic Study on Chlorosulfolipid toward elucidation of toxicity

根据该方案，对氯硫脂的两个片段的合成以及与片段的偶联反应条件进行了考察。作为检查的结果，开发了一个片段的有效合成，并建立了另一个片段的合成的新合成方法。该方法用于一步合成，-不饱和酮与醛，三甲基甲硅烷基甲基膦酸酯和酰氟，并发表在杂志，有机快报。目前正在使用该方法合成氯硫脂。

According to the plan, the synthesis of two fragments for the chlorosulfolipid and a coupling reaction conditions with the fragments were examined. As a results of the examinations, the efficient synthesis of one fragment was developed, and a new synthetic method for the synthesis of another fragment was established. The method is used for the synthesis of, -unsaturated ketone with aldehyde, trimethylsilylmethyl phosphonate, and acyl fluoride in one step, and published from a journal, Organic Letters. Synthesis of chlorosulfolipid is currently underway using the method.