Studies on the Relationship between the Triple Helical Structure and Immunostimulatory Activity of beta-glucan

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The secondary and higher-order structure of oligo- and polysaccharides has been suggested to be important in exhibiting their biological activity; however, few methods have been available to study their relationship. In this study, through basic studies on vibrational circular dichroism (VCD), we developed a "VCD exciton chirality method", which allowed us to study stereostructures of complex molecules. By using this method, we successfully detected the conformational changes of beta glucan triple helix. Aiming at identifying the minimum structure of beta glucan to form triple helix, we also developed a new method to synthesize short beta glucan.