Bioprospecting in untapped microbes for new drug discovery resources

为了丰富药物发现资源的结构多样性，人们对未开发的微生物进行了探索以寻找新的生物活性分子。从炎热或水生环境中收集的细菌发酵产物以及包括活性污泥和生物垫在内的细菌菌群制备的提取物，筛选了针对由革兰氏阳性/阴性细菌、酵母和真菌组成的 9 种菌株的抗生素作用。对几种热门提取物进行了详细的化学研究，结果从三种水生细菌中发现了 7 种新的生物活性代谢物，属于三个结构类别。我们的生物勘探战略应有助于有效扩大药物开发的化学品库。

As an attempt to enrich the structural diversity of drug discovery resources, untapped microbes were prospected for new bioactive molecules. Extracts prepared from the fermentation products of bacteria collected from hot or aquatic environments and bacterial consortia including activated sludges and a biomat werescreened for antibiotic actions against 9 strains composed of Gram-positive/-negative bacteria, yeasts, and fungi. Several of the hit extracts were subjected to detailed chemical studies, which resulted in the discovery of 7 new bioactive metabolites belonging to threestructure classes from three aquatic bacteria. Our bioprospecting strategy should facilitate effective expansion of the chemical reservoir for pharmaceutical developments.