Effect of Ethereal Oxygens on the Biological Activities of Ladder-Shaped Polyethers

梯形聚醚主要是由甲藻产生的海洋毒素。本研究的目的是阐明梯形聚醚如何在我们体内发挥其毒性。在天然产物的合成研究中，首先合成基本部分（积木），然后利用这些部分构建目标分子。然而，在本研究中，我们面临的困难，合成大量的零件，通过传统的方法。因此，建立了新的配方，以成功地提供足够的积木。这一结果将大大加快建设工程，受到世界各地的挑战。

Ladder-shaped polyethers are mainly marine toxins produced by dinoflagellates. The objective of this research was to clarify how the ladder-shaped polyethers work in our bodies to exert their toxicity.In the synthetic studies of natural products, basic parts (building blocks) are first synthesized and a target molecule will be built up using these parts. However, in this research, we faced difficulties in synthesizing a large quantity of parts by traditional methods. Therefore, novel recipe was established to supply enough building blocks successfully. This result will drastically accelerate the building-up works, being challenged all over the world.