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Study of chiral imaging sensors using induced circularly polarized luminescence from rare earth complexe

稀土配合物诱导圆偏振发光手性成像传感器的研究

基本信息

批准号：
23750060
负责人：
IWAMURA Munetaka
金额：
$ 3万
依托单位：
University of Toyama
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2011
资助国家：
日本
起止时间：
2011 至 2012
项目状态：
已结题

项目摘要

Induced circularly polarized luminescence （iCPL) from emitting probe molecules has been studied for the structure of the probes and environment around the complex. Rare-earth complexes such as [Eu（pda)2]-（pda = 1,10 phenanthroline 2,9 dicarboxylic acid) have been selected as the probes due to their high emissive properties and relatively large g values, and its achiral structures. When the rare-earth complexes exhibit CPL in spite of their achiral structures, the observation will mean that the structure of the complex is distorted to chiral by other chiral molecules or environments. This type of iCPL is available for chiral sensing system. The CPL sensing system has a potential to be employed in a microscopic sensing system with high sensitivity, and a single molecule CPL spectroscopy. In this view point, we have searched achiral emissive rare earth complexes which are likely distorted to chiral structure and show strong CPL signal when they sense chiral molecules or environments. We found [Eu（pda)2]-and [Eu（bda)2]-（bda = 2,2’-bipyridine-6,6’-dicarboxic acid) exhibits intense iCPL by some amino acids such as S（R)-2-Pyrrolidone-5-Carboxylic acid in aqueous solution. Furthermore, we have examined iCPL detection via microscopic system and made iCPL mapping for a conjugatedsystem using [Eu（pda)2]-as a iCPL probe molecule.

从发射探针分子的诱导圆偏振发光（iCPL）已被研究的探针的结构和周围的复杂环境。稀土配合物如[Eu（pda）2]-（pda = 1，10-菲咯啉-2，9-二羧酸）由于其高的发光性能和相对较大的g值以及其非手性结构而被选为探针。当稀土配合物尽管具有非手性结构，但仍表现出CPL时，这意味着配合物的结构被其他手性分子或环境扭曲为手性。这种类型的iCPL可用于手性传感系统。CPL传感系统具有应用于高灵敏度的显微传感系统和单分子CPL光谱学的潜力。基于这一观点，我们寻找了一类非手性发光稀土配合物，这些配合物在检测手性分子或环境时，很可能被扭曲成手性结构，并显示出强的CPL信号。我们发现[Eu（pda）2]-和[Eu（bda）2]-（bda = 2，2 '-bipyridine-6，6'-dicarboxylic acid）在水溶液中对某些氨基酸如S（R）-2-Pyrrolidone-5-Carboxylic acid表现出强烈的iCPL。此外，我们还研究了显微系统对iCPL的检测，并以[Eu（pda）2]-为探针分子，对共轭体系进行了iCPL作图。