Optimization of cytokine gene therapy based on the regulation of transcription/translation, pharmacokinetics, and cellular response.
Optimization of cytokine gene therapy based on the regulation of transcription/translation, pharmacokinetics, and cellular response.
批准号:
24390008
负责人:
TAKAKURA Yoshinobu
金额:
$11.9万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2015-03-31
中文摘要
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英文摘要
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Upregulation of indoleamine 2, 3-dioxygenase 1 by interferon γ gene transfer and its effects on tumor growth in mice.
干扰素 γ 基因转移上调吲哚胺 2, 3-双加氧酶 1 及其对小鼠肿瘤生长的影响。
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Kanitta Watcharanurak, Lei Zang, Makiya Nishikawa, Kayo Yoshinaga, Yuki Takahashi, Yasuko Yamamoto, Kuniaki Saito, Yuki Murakami, Yoshinobu Takakura]
通讯作者:
Yoshinobu Takakura
Removal of transgene-expressing cells by transgene-specific immune response induced by sustained transgene expression.
通过持续转基因表达诱导的转基因特异性免疫反应去除转基因表达细胞。
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Yalei Yin, Norifumi Ebisuura, Yuki Takahashi, Makiya Nishikawa, Yoshinobu Takakura]
通讯作者:
Yoshinobu Takakura
Controlling thekinetics of interferon transgene expression lor improved gene therapy.
控制干扰素转基因表达的动力学以改善基因治疗。
DOI:
10.3109/1061186x.2012.716848
发表时间:
2012
期刊:
Journal of Drug Targeting
影响因子:
4.5
作者:
[Watcharanurak K, Nishikawa M, Takahashi Y, Takakura Y.]
通讯作者:
Takakura Y.
細胞表面接着型インターフェロンを利用した標的特異的作用型遺伝子治療システムの開発
使用细胞表面附着的干扰素开发靶标特异性基因治疗系统
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[高橋有己, 安藤 満, 西川元也, 渡部好彦, 高倉喜信]
通讯作者:
高倉喜信
マウスにおけるRNA干渉効果の定量的解析法の開発
小鼠RNA干扰效应定量分析方法的建立
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[高橋有己, 松井由梨子, 西川元也, 高倉喜信]
通讯作者:
高倉喜信
共 12 条
Design and delivery of plasmid vector for spatiotemporal control of the expression of therapeutic protein and siRNA
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批准号:21390009
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.73万
-
财政年份:2009
-
负责人:TAKAKURA Yoshinobu
-
依托单位:
Development of all inclusive anti tumor immunotherapy based on engineered protein and nucleic acid
-
批准号:19390041
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$12.31万
-
财政年份:2007
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负责人:TAKAKURA Yoshinobu
-
依托单位:
Design and delivery of nucleic acid drugs for optimization of DNA vaccination
-
批准号:17390041
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.6万
-
财政年份:2005
-
负责人:TAKAKURA Yoshinobu
-
依托单位:
Establishment of novel delivery strategies to dendritic cells and optimization of DNA vaccination
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批准号:15390048
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.34万
-
财政年份:2003
-
负责人:TAKAKURA Yoshinobu
-
依托单位:
Development of plasmid DNA delivery methods to antigen presenting cells for optimized DNA vaccination
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批准号:13470514
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.04万
-
财政年份:2001
-
负责人:TAKAKURA Yoshinobu
-
依托单位:
Development of local drug disposition analysis and delivery methods in human solid tumors
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批准号:12557212
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.46万
-
财政年份:2000
-
负责人:TAKAKURA Yoshinobu
-
依托单位:
遺伝子医薬品の体内動態および細胞取り込み機構の解明に基づくデリバリー戦略の確立
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批准号:11672257
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:1999
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负责人:TAKAKURA Yoshinobu
-
依托单位:
Development of Gene Delivery Systems to Intestinal Epithelial Cells as a Target
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批准号:09672324
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.43万
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财政年份:1997
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负责人:TAKAKURA Yoshinobu
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依托单位:
Development of Delivery Systems for the Control of Pharmacokinetics and Intracellular Trafficking of Antisense Drugs
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批准号:07672351
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:1995
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负责人:TAKAKURA Yoshinobu
-
依托单位:
海外基金