Micro RNA expressions of chronic hepatitis related hepatocellular carcinoma

慢性肝炎相关性肝细胞癌中微小RNA的表达

• 批准号: 24790686
• 负责人: UEDA TERUYUKI
• 金额: $ 2.83万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790686/
• 关键词: 肝細胞癌; ウイルス性肝疾患; 遺伝子発現解析; 肝癌; 遺伝子発現

DNA damage response genes in non-tumor lesions were associated with AP1 signaling which mediates the expression of many genes in CH-B-related HCC. In contrast, signal transducers and activators of transcription 1 and phosphatase and tensin homolog in non-tumor lesions were associated with early growth response protein 1 signaling that potentially promotes angiogenesis, fibrogenesis, and tumorigenesis in CH-C-related HCC. MicroRNAs were up- or down-regulated in cancerous tissue. These expression changes were confirmed as previously.Gene expression profiling of HCC and non-tumor lesions revealed the predisposing changes of gene expression in HCC. This approach has potential for the early diagnosis and possible prevention of HCC.

非肿瘤病变中的DNA损伤应答基因与AP1信号相关，AP1信号介导ch - b相关性HCC中许多基因的表达。相反，非肿瘤病变中转录1、磷酸酶和紧张素同源物的信号转导和激活因子与早期生长反应蛋白1信号相关，该信号可能促进ch - c相关HCC的血管生成、纤维生成和肿瘤发生。microrna在癌组织中被上调或下调。这些表达变化与之前一样得到证实。HCC和非肿瘤病变的基因表达谱揭示了HCC中基因表达的易感性变化。这种方法具有早期诊断和预防HCC的潜力。

项目成果

Gene expression profiling of hepatitis B- and hepatitis C-related hepatocellular carcinoma using graphical Gaussian modeling

• DOI: 10.1016/j.ygeno.2013.02.007
• 发表时间: 2013-04-01
• 期刊: GENOMICS
• 影响因子: 4.4
• 作者: Ueda, Teruyuki;Honda, Masao;Kaneko, Shuichi
• 通讯作者: Kaneko, Shuichi