Micro RNA expressions of chronic hepatitis related hepatocellular carcinoma

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DNA damage response genes in non-tumor lesions were associated with AP1 signaling which mediates the expression of many genes in CH-B-related HCC. In contrast, signal transducers and activators of transcription 1 and phosphatase and tensin homolog in non-tumor lesions were associated with early growth response protein 1 signaling that potentially promotes angiogenesis, fibrogenesis, and tumorigenesis in CH-C-related HCC. MicroRNAs were up- or down-regulated in cancerous tissue. These expression changes were confirmed as previously.Gene expression profiling of HCC and non-tumor lesions revealed the predisposing changes of gene expression in HCC. This approach has potential for the early diagnosis and possible prevention of HCC.