Micro RNA expressions of chronic hepatitis related hepatocellular carcinoma

非肿瘤组织中的DNA损伤反应基因与AP1信号通路有关，AP1信号通路介导了CH-B相关肝细胞癌中多个基因的表达。相反，非肿瘤病变中的信号转导和转录激活因子1以及磷酸酶和张力蛋白同源物与早期生长反应蛋白1信号有关，该信号可能促进CH-C相关肝细胞癌的血管生成、纤维化和肿瘤形成。在癌组织中，microRNAs表达上调或下调。肝细胞癌和非肿瘤病变的基因表达谱揭示了肝细胞癌基因表达的易感性变化。该方法对肝细胞癌的早期诊断和预防具有潜在的应用价值。

DNA damage response genes in non-tumor lesions were associated with AP1 signaling which mediates the expression of many genes in CH-B-related HCC. In contrast, signal transducers and activators of transcription 1 and phosphatase and tensin homolog in non-tumor lesions were associated with early growth response protein 1 signaling that potentially promotes angiogenesis, fibrogenesis, and tumorigenesis in CH-C-related HCC. MicroRNAs were up- or down-regulated in cancerous tissue. These expression changes were confirmed as previously.Gene expression profiling of HCC and non-tumor lesions revealed the predisposing changes of gene expression in HCC. This approach has potential for the early diagnosis and possible prevention of HCC.