Mechanisms of temporal and spatial control of cardiac fibroblasts in myocardial infarction

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Ischemic heart disease is one of the highest mortality for both men and women in all developed countries. Myocardial infarction is caused by the occlusion of blood supply such as thrombus or arteriosclerosis in coronary artery. After myocardial infarction, cardiomyocytes die due to lack of oxygen and nutrients. It is known that cardiomyocyte death is followed by fibrosis that leads to heart failure. Therefore, it is crucial for controlling the fibrosis in myocardial infarction.In this study, we suggest a new therapeutic target for myocardial infarction to inhibit fibrosis by controlling metabolic adaptation in cardiac fibroblasts.