Influence of L-lysine on uremic memory

血管钙化是慢性肾脏疾病危及生命的并发症之一。L赖氨酸对腺嘌呤尿毒症大鼠动脉钙化的保护作用。膳食L赖氨酸强烈抑制腺嘌呤大鼠血浆全段甲状旁腺激素，从而支持适当的骨-血管轴。饲粮中添加L赖氨酸可提高血浆丙氨酸、脯氨酸、精氨酸和高精氨酸水平，但不能提高赖氨酸水平。体外分析表明，丙氨酸和脯氨酸可抑制培养的血管平滑肌细胞的凋亡，精氨酸和高精氨酸可减少钙/磷过饱和溶液中的矿物质沉淀。膳食补充L赖氨酸通过改变加重VC的几个关键途径来改善VC。

Vascular calcification is one of the life-threatening complications of chronic kidney disease. Dietary L-lysine prevented arterial calcification in adenine-induced uremic rats. Dietary L-lysine strongly suppressed plasma intact parathyroid hormone in adenine rats, and thereby supported a proper bone-vascular axis. Dietary L-lysine elevated plasma alanine, proline, arginine, and homoarginine but not lysine. Analyses in vitro demonstrated that alanine and proline inhibit apoptosis of cultured vascular smooth muscle cells, and that arginine and homoarginine attenuate mineral precipitations in a supersaturated calcium/phosphate solution. Dietary supplementation of L-lysine ameliorated VC by modifying several key pathways that exacerbate VC.