Development of procine model to establish the specific treatment for IgA nephropathy

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Though immunological disorders in mucosa with a focus on tonsils are suggested to be involved in the pathogenesis of human IgA nephropathy (IgAN), there are no appropriate animal models bearing tonsils. Since it was reported that porcine develop spontaneous renal lesions resembling human IgAN in addition to bearing tonsils, we focused on porcine as a novel animal models of IgAN. After we confirmed that micro-minipigs (MMPs) develop spontaneous renal lesions resembling human IgAN as well as other types of porcine, we started to compare the phenotype containing renal lesions between MMPs in the natural course group (natural course G) and those in the tonsillectomy group (tonsillectomy G). Immunofluorescence stainings indicated that the intensity of glomerular deposition of immunogloblin containing IgA in MMPs of tonsillectomy G may be lower than that of natural course G at eight months old. Now we are continuing the comparison of phenotype with a focus on renal lesions.