Evaluation of neuropathic pain system using pain-related evoked potentials with C fiber selective electrical stimulation

点击翻译按钮获取中文摘要

We investigated patterns of changes in A delta- and C-mediated brain responses in neuropathic pain, using pain-related evoked potentials (PREPs) with intra-epidermal electrical stimulation (IES) for evaluation of neuropathic pain system. Patients with neuropathic pain have increased C/A delta fiber-PREP amplitude ratios, possibly due to decreased inhibition of the A delta to C nociceptive system leading to generation of neuropathic pain. PREPs with IES could be a useful tool to evaluate changes in neural responses and interaction of the A delta- and C-mediated pain pathways in neuropathic pain patients.