Molecular mechanisms of diabetic lipemia in streptozotocin-treated mice

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The molecular mechanism of diabetic lipemia in the setting of insulin deficiency is not fully understood. We have previously found that the plasma level of triglycerides is lower in hormone-sensitive lipase (HSL) deficient mice than in wild-type mice when they are challenged with streptozotocin. The current study was aimed at elucidating the molecular mechanism of diabetic lipemia through the detailed analysis of HSL-deficient mice in the insulin-deficient status. We found that the enzymatic activity and mRNA levels of lipoprotein lipase (LPL) were not significantly different between wild-type and HSL-deficient mice in the insulin-deficient status. Other factors that regulate LPL activity in vivo or other pathways such as intestinal lipid absorption may explain the phenotypic difference, which are currently under investigation.