Investigation of Serum Aldosterone Inducing Factors in Patients with Idiopathic Hyperaldosteronism

醛固酮分泌腺瘤（APA）和双侧特发性高醛固酮增多症（IHA）是原发性醛固酮增多症最常见的亚型。IHA的病因尚不清楚，根治IHA的方法尚未确定。在我们的研究中，我们发现1)尿醛固酮分泌仅在IHA患者中与体重指数、腹围、空腹血糖和HOMA-R呈正相关，而在APA和非pa患者中均无相关；2)IHA患者血清促进醛固酮分泌的能力与患者醛固酮和内脏脂肪面积呈正相关。这些结果表明,有CYP11B2激活因素来自内脏脂肪的血清IHA病人和有可能提高宫内厅的改善肥胖。

Aldosterone-producing adenoma (APA) and bilateral idiopathic hyperaldosteronism (IHA) are the most common subtypes of primary aldosteronism. The etiology of IHA is still unknown and the radical treatment for IHA is not established.In our study, we have shown that 1) urinary aldosterone secretion positively correlated with body mass index, abdominal circumference, fasting blood glucose and HOMA-R only in patients with IHA, not in APA and non-PA patients and 2)the ability to promote aldosterone secretion by serum of IHA patients positively correlated with patients' aldosterone and visceral fat area.These results suggest that there are CYP11B2 activating factors derived from visceral fat in serum of IHA patients and there is a possibility that IHA is improved by amelioration of obesity.