The study of change in acute ischemic stroke used by a new diffusion MRI metric: QSI/DKI

以脑白质、皮层、小脑、脑干或基底节区梗死为主要表现的脑卒中患者27例（发病后3小时~29天）。所有受试者在1.5T MR扫描仪上进行更先进的弥散成像（diffusion kurtosis imaging， DKI）和常规弥散成像（diffusion tensor imaging， DTI）扫描。为每个脑卒中病变定义感兴趣的区域。DKI参数：计算平均扩散峰度（MDK）和DTI参数。结果表明MDK添加了不同于DTI的病理信息。简而言之，MDK的值表明了组织的复杂性。有助于我们了解脑卒中病变的病理变化。MDK图比常规弥散显像提前1个月预测脑卒中病变的预后。

Subjects were 27 stroke patients presenting with cerebral white matter, cortex, cerebellum, brainstem or basal ganglia infarction (time after onset= 3hours~29days). All subjects were scanned Diffusional kurtosis imaging (DKI) that is more advanced diffusional imaging and diffusion tensor imaging (DTI) that is conventional diffusional imaging on 1.5T MR scanner. Regions of interest were defined for each stroke lesion. Parameter of DKI: mean diffusional kurtosis (MDK) and DTI parameters were calculated. In result, it indicates that MDK add pathological information differing from DTI. In short, the value of MDK indicates complexity of the tissue. It helps us to understand pathological change of stroke lesion. And MDK map can predict the outcome of stroke lesion 1 month earlier than conventional diffusional imaging.