The study of change in acute ischemic stroke used by a new diffusion MRI metric: QSI/DKI

卒中患者27例，表现为脑白质、皮质、小脑、脑干或基底节梗死(发病时间3h~29d)。所有受试者均行1.5T磁共振扩散峰成像(DKI)和常规弥散张量成像(DTI)检查。为每个卒中病变定义感兴趣区。DKI参数：计算平均弥散峰度(MDK)和弥散张量成像参数。结果表明，MDK增加了不同于DTI的病理信息。简而言之，MDK的值表示组织的复杂性。有助于我们了解卒中病变的病理变化。MDK图较常规弥散成像能提前1个月预测卒中病变的预后。

Subjects were 27 stroke patients presenting with cerebral white matter, cortex, cerebellum, brainstem or basal ganglia infarction (time after onset= 3hours~29days). All subjects were scanned Diffusional kurtosis imaging (DKI) that is more advanced diffusional imaging and diffusion tensor imaging (DTI) that is conventional diffusional imaging on 1.5T MR scanner. Regions of interest were defined for each stroke lesion. Parameter of DKI: mean diffusional kurtosis (MDK) and DTI parameters were calculated. In result, it indicates that MDK add pathological information differing from DTI. In short, the value of MDK indicates complexity of the tissue. It helps us to understand pathological change of stroke lesion. And MDK map can predict the outcome of stroke lesion 1 month earlier than conventional diffusional imaging.