Early detection of acute kidney injury following organ transplantation and assessment of recovery using new markers

使用新标记物早期检测器官移植后的急性肾损伤并评估恢复情况

• 批准号: 24791592
• 负责人: IGUCHI Naoya
• 金额: $ 2.75万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791592/
• 关键词: 臓器移植; 急性腎障害

P-NGAL, U-NGAL/Cr and L-FABP/Cr upon ICU admission (n=25) were unrelated to acute kidney injury (AKI) development (p = 0.24, 0.22, and 0.53, respectively). There were no differences in P-NGAL, U-NGAL/Cr, and L-FABP/Cr levels from day 1 to day 6 between patients who did not recover from AKI and patients who recovered from AKI (p = 0.82, 0.26, and 0.61, respectively). Our findings suggest that NGAL and L-FABP upon ICU admission are not predictive of AKI and serial NGAL and L-FABP measurements may be ineffective for monitoring the status and treatment of post transplantation AKI. The resistive index (RI) did not correlate with pulse pressure index (PI) (n=12), suggesting that PI may not be necessarily considered when predicting AKI using RI. We reported that adjustment of creatinine level for preoperative fluid balance could improve the accuracy of AKI diagnosis after cardiac surgery.

入院时P-NGAL、U-NGAL/Cr和L-FABP/Cr与急性肾损伤无关(P分别为0.24、0.22和0.53)。发病第1~6天，未恢复组与恢复组P-NGAL、U-NGAL/Cr、L-FABP/Cr水平差异无统计学意义(P分别为0.82、0.26、0.61)。我们的研究结果表明，入院时的NGAL和L-FABP不能预测移植后急性KI的发生，连续测定NGAL和L-FABP对监测移植后AKI的病情和治疗可能无效。阻力指数(RI)与脉压指数(PI)无相关性(n=12)，提示用RI预测AKI时不一定要考虑PI。我们报道，调整术前体液平衡水平可以提高心脏手术后AKI诊断的准确性。

项目成果

臓器移植後患者の NGAL 値の検討

器官移植后患者NGAL值的检查

• 发表时间: 2013
• 作者: 井口 直也;内山 昭則;植田 一吉;藤野裕士
• 通讯作者: 藤野裕士

Early prediction of acute kidney injury biomarkers after endovascular stent graft repair of aortic aneurysm: a prospective observational study.

• DOI: 10.1186/s40560-014-0045-4
• 发表时间: 2014
• 期刊: Journal of intensive care
• 影响因子: 7.1
• 作者: Ueta K;Watanabe M;Iguchi N;Uchiyama A;Shirakawa Y;Kuratani T;Sawa Y;Fujino Y
• 通讯作者: Fujino Y

Neutrophil gelatinase-associated lipocalin (NGAL) in patients after organ translantation

器官移植后患者中性粒细胞明胶酶相关脂质运载蛋白（NGAL）

• 发表时间: 2013
• 作者: Naoya Iguchi;Akinori Uchiyama;Kazuyoshi Ueta;Yuji Fujino
• 通讯作者: Yuji Fujino

臓器移植術後患者のNGAL値の検討

器官移植手术后患者NGAL值的检查

• 作者: 井口 直也;内山 昭則;植田 一吉;藤野 裕士
• 通讯作者: 藤野 裕士

腎臓超音波検査 resistive index(RI)と血圧 pulse pressure index(PI)の関係の検討

肾脏超声检查阻力指数（RI）与血压脉压指数（PI）关系的探讨

• 发表时间: 2014
• 作者: 井口 直也;酒井 佳奈紀;内山 昭則;藤野 裕 士
• 通讯作者: 藤野 裕 士