Early detection of acute kidney injury following organ transplantation and assessment of recovery using new markers

ICU入院时的P-NGAL、U-NGAL/Cr和L-FABP/Cr（n=25）与急性肾损伤（阿基）的发生无关（分别为p = 0.24、0.22和0.53）。从第1天到第6天，未从阿基恢复的患者和从阿基恢复的患者之间的P-NGAL、U-NGAL/Cr和L-FABP/Cr水平没有差异（分别为p = 0.82、0.26和0.61）。我们的研究结果表明，ICU入院时NGAL和L-FABP不能预测阿基，连续NGAL和L-FABP测量可能对监测移植后阿基的状态和治疗无效。阻力指数（RI）与脉压指数（PI）无相关性（n=12），提示使用RI预测阿基时可能不一定考虑PI。我们报告，术前调整肌酐水平以实现液体平衡可提高心脏手术后阿基诊断的准确性。

P-NGAL, U-NGAL/Cr and L-FABP/Cr upon ICU admission (n=25) were unrelated to acute kidney injury (AKI) development (p = 0.24, 0.22, and 0.53, respectively). There were no differences in P-NGAL, U-NGAL/Cr, and L-FABP/Cr levels from day 1 to day 6 between patients who did not recover from AKI and patients who recovered from AKI (p = 0.82, 0.26, and 0.61, respectively). Our findings suggest that NGAL and L-FABP upon ICU admission are not predictive of AKI and serial NGAL and L-FABP measurements may be ineffective for monitoring the status and treatment of post transplantation AKI. The resistive index (RI) did not correlate with pulse pressure index (PI) (n=12), suggesting that PI may not be necessarily considered when predicting AKI using RI. We reported that adjustment of creatinine level for preoperative fluid balance could improve the accuracy of AKI diagnosis after cardiac surgery.