Identification of characteristic gene expression and molecular target in sarcomatoid renal cell carcinoma

肉瘤样肾细胞癌特征基因表达和分子靶标的鉴定

• 批准号: 24791634
• 负责人: KOJIMA Takahiro
• 金额: $ 2.66万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791634/
• 关键词: 肉腫様腎細胞癌; 遺伝子異常; DNAコピー数異常; マイクロアレイ

We selected and analyzed ETV5, TOP2, RAC and VAV1 for candidate targets among up-regulated genes in sarcomatoid renal cell carcinoma. These genes were significantly up-regulated in sarcomatoid component compared with clear cell component. Suppression of these genes by siRNA resulted in suppression of cell proliferation of renal cell carcinoma cell lines. Our results may represent a novel biomarker and therapeutic target for patients with sarcomatoid renal cell carcinoma.

我们选择并分析了ETV 5、TOP 2、RAC和VAV 1作为肉瘤样肾细胞癌中上调基因的候选靶基因。与透明细胞组相比，肉瘤样组中这些基因表达显著上调。通过siRNA抑制这些基因导致肾细胞癌细胞系的细胞增殖抑制。我们的研究结果可能为肉瘤样肾细胞癌患者提供一种新的生物标志物和治疗靶点。

项目成果

Oncological outcomes of metastatic testicular cancers under centralized management through regional medical network

通过区域医疗网络集中管理转移性睾丸癌的肿瘤结果

• DOI: 10.1093/jjco/hyt152
• 发表时间: 2013
• 期刊: Jpn J Clin Oncol
• 影响因子: 2.4
• 作者: Inai H;Kawai K;Kojima T;Joraku A;Shimazui T;Yamauchi A;Miyagawa T;Endo T;Fukuhara Y;Miyazaki J;Uchida K;Nishiyama H
• 通讯作者: Nishiyama H

Management of ureteral obstruction in advanced testicular tumor with lymph node metastasis

晚期睾丸肿瘤伴淋巴结转移输尿管梗阻的处理

• DOI: 10.1093/jjco/hys094
• 发表时间: 2012
• 期刊: Jpn J Clin Oncol
• 影响因子: 2.4
• 作者: Ikeda A;Kawai K;Miyazaki J;Nishiyama H.
• 通讯作者: Nishiyama H.

A Case of Acute Adrenal Insufficiency Unmasked During Sunitinib Treatment for Metastatic Renal Cell Carcinoma

• DOI: 10.1093/jjco/hys070
• 发表时间: 2012-08-01
• 期刊: JAPANESE JOURNAL OF CLINICAL ONCOLOGY
• 影响因子: 2.4
• 作者: Yoshino, Takayuki;Kawai, Koji;Nishiyama, Hiroyuki
• 通讯作者: Nishiyama, Hiroyuki

Systemic transduction of p16INK4A antitumor peptide inhibits the growth of MBT-2 mouse bladder tumor cell line grafts

• DOI: 10.3892/ijo.2012.1752
• 发表时间: 2013-02-01
• 期刊: INTERNATIONAL JOURNAL OF ONCOLOGY
• 影响因子: 5.2
• 作者: Shimazui, Toru;Yoshikawa, Kazuhiro;Nishiyama, Hiroyuki
• 通讯作者: Nishiyama, Hiroyuki

Genome-wide identification of endothelial cell-enriched genes in the mouse embryo

• DOI: 10.1182/blood-2011-12-398156
• 发表时间: 2012-07-26
• 期刊: BLOOD
• 影响因子: 20.3
• 作者: Takase, Haruka;Matsumoto, Ken;Ema, Masatsugu
• 通讯作者: Ema, Masatsugu