Adipocytokines and follicular development

脂肪细胞因子和卵泡发育

• 批准号: 24791681
• 负责人: HARA Shuichiro
• 金额: $ 2.58万
• 依托单位: Yamagata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791681/
• 关键词: アディポサイトカイン; 卵胞体外培養; インスリン抵抗性改善薬; 多嚢胞性卵巣症候群; PPAR-γ作動薬

Polycystic ovary syndrome (PCOS) is a common ovulatory disorder in young women. We examined to clarify the pathogenesis of PCOS by using an in vitro mouse preantral follicle culture system. TNF-alpha is an aipocytokine, which raise insulin resistance. TNF-alpha directly inhibited follicular development. On the other hand, insulin-sensitizing drugs restored the TNF-alpha-mediated inhibition of follicular development.

多囊卵巢综合征（PCOS）是年轻女性常见的排卵障碍。本研究采用小鼠腔前卵泡体外培养系统，探讨PCOS的发病机制。TNF-α是一种脂细胞因子，可引起胰岛素抵抗。TNF-α直接抑制卵泡发育。另一方面，胰岛素增敏药物恢复了TNF-α介导的卵泡发育抑制。

项目成果

ピオグリタゾンの卵胞発育促進作用の検討

吡格列酮促卵泡生长作用的考察

• 发表时间: 2012
• 作者: Hara S;Takahashi T;Amita M;Matsuo K;Igarashi H;Kurachi H;Shuichiro Hara;原周一郎
• 通讯作者: 原周一郎

Pioglitazone counteracts the tumor necrosis factor-alpha inhibition of follicle-stimulating hormone-induced follicular development and estradiol production in an in vitro mouse preantral follicle culture system

在体外小鼠腔前卵泡培养系统中，吡格列酮抵消肿瘤坏死因子-α对促卵泡激素诱导的卵泡发育和雌二醇产生的抑制作用

• 发表时间: 2013
• 期刊: Jurnal of ovarian research
• 作者: Hara S;Takahashi T;Amita M;Matsuo K;Igarashi H;and Kurachi H
• 通讯作者: and Kurachi H

Peroxisome proliferator-activated receptor-γ agonists prevent tumor necrosis factor-α-mediated inhibition of FSH-induced follicle development and estradiol production in a preantral follicle culture system

过氧化物酶体增殖物激活受体-γ 激动剂可防止肿瘤坏死因子-α 介导的对窦前卵泡培养系统中 FSH 诱导的卵泡发育和雌二醇产生的抑制

• 发表时间: 2014
• 期刊: Journal of mammalian ova research
• 作者: Hara S;Takahashi T;Igarashi H;Amita M;Matsuo K;Hasegawa A;and Kurachi H
• 通讯作者: and Kurachi H

Effects of pioglitazone on follicular development and steroidogenesis in in vitro mouse preantral follicle culture

吡格列酮对体外小鼠腔前卵泡培养中卵泡发育和类固醇生成的影响

• 发表时间: 2012
• 作者: Hara S;Takahashi T;Amita M;Matsuo K;Igarashi H;Kurachi H;Shuichiro Hara
• 通讯作者: Shuichiro Hara