Differentiation induction from embryonic stem cells to functional thyroid tissues

胚胎干细胞向功能性甲状腺组织的分化诱导

• 批准号: 24791762
• 负责人: KANNO Masafumi
• 金额: $ 2.66万
• 依托单位: University of Fukui
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791762/
• 关键词: ES細胞; 甲状腺; Ｌｒｈ－１; 胚性癌細胞; 甲状腺濾胞上皮細胞; 内胚葉; F9細胞; Lrh-1

Differentiation induction from embryonic stem cells to thyroid tissues, which we is our objective, was accomplished by Dr. Antonica and others from Belgium in 2012, leading to transplantation into the body of a mouse and thus to recovery of thyroid function (Nature 491(7422):66-71.2012).We inferred an important relation between this differentiation efficacy and the potency of embryonic stem cells to maintain the undifferentiated state. We analyzed it further to improve the differentiation induction efficacy of embryonic stem cells. Results demonstrated that the liver receptor homologue 1 (LRH1), which we specifically examined, was induced directly by Sox2 and Gabp. It played an important role in self renewal.

Differentiation induction from embryonic stem cells to thyroid tissues, which we is our objective, was accomplished by Dr. Antonica and others from Belgium in 2012, leading to transplantation into the body of a mouse and thus to recovery of thyroid function (Nature 491(7422):66-71.2012).We inferred an important relation between this differentiation efficacy and the potency of embryonic stem cells to maintain the undifferentiated 状态。我们进一步分析了它，以提高胚胎干细胞的分化诱导功效。结果表明，我们特别检查的肝受体同源物1（LRH1）是由Sox2和GABP直接诱导的。它在自我更新中发挥了重要作用。