Leukotriene receptor variation and it's role in intractable eoshinophilic rhino sinusitis.

白三烯受体变异及其在顽固性嗜酸性鼻窦炎中的作用。

• 批准号: 24791791
• 负责人: OHORI Junichiro
• 金额: $ 2.75万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791791/
• 关键词: 好酸球; 上皮; VEGF; ロイコトリエン

In order to investigate the role of cysteinyl leukotriene receptor 2 (CysLT2R) in eoshinophilic rhino sinusitis, the production of VEGF from Epithelial cells, the expression of CysLT2R on eosinophil, and the interaction between epithelial cells and eosinophil were examined. It was observed that the autocrine effect in VEGF production on the epithelial cell of nasal mucosa. The expression of CysLT2R was higher than that of CysLT1R on eosinophil. Further, the accentuation of VEGF production was observed in coculture of epithelial cells and eosinophils. These data suggested that CysLT2R and VEGF were one of the couse regarding the refractory pathology of eosinophilic rhino sinusitis.

为探讨半胱氨酰白三烯受体2(CysLT2R)在嗜酸性鼻窦炎发病机制中的作用，对嗜酸性鼻窦炎上皮细胞产生血管内皮生长因子(VEGF)、嗜酸性粒细胞上CysLT2R的表达以及上皮细胞与嗜酸性粒细胞之间的相互作用进行了研究。观察到自分泌对鼻黏膜上皮细胞产生血管内皮生长因子的影响。嗜酸性粒细胞上CysLT2R的表达高于CysLT1R。此外，在上皮细胞和嗜酸性粒细胞的共同培养中观察到血管内皮生长因子的产生增加。提示CysLT2R和血管内皮生长因子是嗜酸性鼻窦炎顽固性病变的原因之一。

项目成果

Vascular Endothelial Growth Factor(VEGF) was produced from Nasa Polyp Epithelial Cells Stimulated with VEGF via upregulation of VEGF Receptor-1

血管内皮生长因子 (VEGF) 是通过上调 VEGF 受体 1 刺激鼻息肉上皮细胞产生的

• 发表时间: 2012
• 作者: Junichiro Ohori;kousuke Yoshifuku;Kurono Yuichi;Junichiro Ohori
• 通讯作者: Junichiro Ohori

Vascular Endothelial Growth Factor(VEGF) was produced from Nasal Polyp Epithelial Cells Stimurated with VEGF vis upregulation of VEGF Receptor-1

血管内皮生长因子 (VEGF) 由 VEGF 刺激的鼻息肉上皮细胞产生，并上调 VEGF Receptor-1

• 发表时间: 2012
• 作者: Junichiro Ohori;kousuke Yoshifuku;Kurono Yuichi
• 通讯作者: Kurono Yuichi