Evaluation of the utility of growth factors for the treatment of hypertrophic scar

生长因子治疗增生性疤痕的效用评价

• 批准号: 24791919
• 负责人: ETO Hitomi
• 金额: $ 2.33万
• 依托单位: Kyorin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791919/
• 关键词: 線維芽細胞; 増殖因子; 瘢痕治療

To evaluate the utility of basic fibroblast growth factor (bFGF) for the treatment of hypertrophic scar, we investigated the effects on cultured fibroblasts of bFGF. On the basis of the findings that dermal fibroblast is mixed population consisted of some subpopulations having differing characteristics, superficial fibroblasts, which express anti-fibrotic factors, and deep fibroblasts, which express pro-fibrotic factors, were isolated and analysed by microarray and real-time PCR. Basic FGF were elucidated to increase the expression of specific factor for superficial fibroblasts, suggesting enhance the capability of the cells to suppress fibrosis.

为了评价碱性成纤维细胞生长因子(BFGF)对增生性瘢痕的治疗作用，我们观察了碱性成纤维细胞生长因子对成纤维细胞的影响。根据真皮成纤维细胞是由具有不同特性的亚群组成的混合群体，利用基因芯片和实时荧光定量聚合酶链式反应分离和分析了表达抗纤维化因子的浅层成纤维细胞和表达促纤维化因子的深层成纤维细胞。碱性成纤维细胞生长因子可促进成纤维细胞特异性因子的表达，从而增强成纤维细胞抑制纤维化的能力。

项目成果

マイクロアレイを用いた真皮浅層線維芽細胞と深層線維芽細胞の比較解析

使用微阵列对浅层和深层真皮成纤维细胞进行比较分析

• 发表时间: 2013
• 作者: 森本訓行;白川真紀子;藤井奈穂;本多典広;粟津邦男;小澤俊幸;森本訓行;森本訓行;江藤ひとみ
• 通讯作者: 江藤ひとみ