Experimental investigation using mice model into development of masticatory and swallowing function under processed food intaking

本研究旨在确定生长期咀嚼功能的“临界期”及临界期后的功能康复能力。用3~20周龄饲喂软、硬颗粒的小鼠进行实验。20周龄时，分别进行显微CT扫描、咀嚼硬质和软质颗粒时的三维颌面运动轨迹和咀嚼肌活动的显微CT扫描，发现功能减退组和康复组在咀嚼硬质颗粒时的颅面形态、三维颌面运动轨迹(尤其是咬合期)和闭合肌肉活动与对照组相比有显著差异。

This is the study to determine the "critical period" of masticatory function in growth period and the faculty of functional rehabilitation after the critical period. It was carried out using mice feeding soft and hard pellet from 3 weeks to 20 weeks old. At 20 weeks, craniofacial skeleton data by micro-CT imaging, and 3D jaw movement path and masticatory muscles activity at hard and soft pellet chewing was taken.As a result, many significantly difference was recognized in craniofacial morphorogy and 3D jaw movement path (especially in occlusal phase) and closing muscles activity at hard pellet chewing in hypofunctional group and rehabilitation group than control feeding hard food.These results suggest that it is impossible in that acquire the certain masticatory function unless hard food feeding in growth period and have never acquire as train with feeding hard food since then.