Asymmetric Synthesis of Amino Acids from Carbon Dioxide

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A catalytic enantioselective silylation of N-tert-butylsulfonylimines using a copper-secondary diamine complex was demonstrated. The resulting optically active amino silanes could be carboxylated under a CO2 atmosphere (1 atm) to afford the corresponding amino acids in a stereoretentive manner. This two-step sequence provides a new synthetic protocol for optically active amino acids from gaseous CO2 and imines in the presence of a catalytic amount of a chiral source.