Analysis of coordinated regulation of metabolism and ovarian development in Drosophila

果蝇代谢与卵巢发育协调调控分析

• 批准号: 24770203
• 负责人: SANO Hiroko
• 金额: $ 3万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24770203/
• 关键词: ショウジョウバエ; 脂肪組織; インシュリン; エクジソン; 生殖幹細胞ニッチ; 内分泌; 生殖巣形成

We have studied the mechanisms as to how the Drosophila adipose tissues regulate ovarian development aiming at clarifying coordinated regulation of metabolism and development. In this study, we found that adipose tissue-derived Insulin (Dilp6) and steroid hormone (20-hydroxyecdysone) regulate the formation of terminal filament, which functions as a part of germline stem cell niche in the ovary.

我们对果蝇脂肪组织调节卵巢发育的机制进行了研究，旨在阐明代谢与发育的协调调节。在本研究中，我们发现脂肪组织源性胰岛素（Dilp6）和类固醇激素（20-羟基蜕皮激素）调节卵巢中作为种系干细胞生态位的一部分的终丝的形成。

项目成果

Analysis of the peripheral tissue-derived peptides, CCHamide-1 and -2, and dRYamide-1 and -2 in Drosophila

果蝇外周组织衍生肽 CCHamide-1 和 -2 以及 dRYamide-1 和 -2 的分析

• 发表时间: 2013
• 作者: Sano;H.;Ida;T.;and Kojima;M.
• 通讯作者: M.

Control of ovarian development by the fat body in Drosophila

果蝇脂肪体对卵巢发育的控制

• 发表时间: 2012
• 作者: Reiko Amikura;Makoto Umemori;Ryusuke Niwa;Yuko Shimada-Niwa;Sora Enya;Naoki Okamoto;Takashi Nishimura;and Hiroko Sano
• 通讯作者: and Hiroko Sano

Analysis of the fat body-derived peptide CCHamide-2 in Drosophila

果蝇脂肪体源性肽 CCHamide-2 的分析

• 发表时间: 2013
• 作者: Sano;H.;Ishimoto;H.;Kamikouchi;A.;Nakamura;A.;Texada;M.;Truman;J.;Ida;T.;and Kojima;M.
• 通讯作者: M.

Nutrition-dependent control of ovarian development by the fat body in Drosophila

果蝇脂肪体对卵巢发育的营养依赖性控制

• 发表时间: 2012
• 作者: Reiko Amikura;Makoto Umemori;Ryusuke Niwa;Yuko Shimada-Niwa;Sora Enya;Naoki Okamoto;Takashi Nishimura;and Hiroko Sano
• 通讯作者: and Hiroko Sano

Isolation of the bioactive peptides CCHamide-1 and CCHamide-2 from Drosophila and their putative role in appetite regulation as ligands for G protein-coupled receptors.

• DOI: 10.3389/fendo.2012.00177
• 发表时间: 2012
• 期刊: Frontiers in endocrinology
• 影响因子: 5.2
• 作者: Ida T;Takahashi T;Tominaga H;Sato T;Sano H;Kume K;Ozaki M;Hiraguchi T;Shiotani H;Terajima S;Nakamura Y;Mori K;Yoshida M;Kato J;Murakami N;Miyazato M;Kangawa K;Kojima M
• 通讯作者: Kojima M