Development of novel platform for injectable in vivo drug delivery system

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The final goal of our study is: (1) to discover the seeds of next-generation biomedicine for infectious disease and cancer therapy; (2) to develop biocompatible materials for supporting surgical treatment. In this study, we focused elastin protein which expresses universally as an elastic fiber of vertebrates. We carried out the rational design and recombinant synthesis of thermally responsive peptide polymer-based hydrogels composed of an elastin-like polypeptide that rapidly forms a reversibly cross-linked hydrogel by the formation of intermolecular mild oxidative cross-links. We showed the utility of the hydrogels for the sustained release of medicines and the ability as to be an injectable and biodegradable material. These materials will find useful application in drug delivery and tissue engineering.