Analysis of p3-Alc peptides, the novel biomarker for Alzheimer's disease

阿尔茨海默病的新型生物标志物 p3-Alc 肽的分析

• 批准号: 24790062
• 负责人: HATA Saori
• 金额: $ 2.83万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790062/
• 关键词: アルツハイマー病

Alzheimerz's disease (AD) is the most common senile dementia. However, the pathogenesis of AD remains unclear. Moreover, early detection methods and fundamental therapeutic methods for AD are not fully established.In this study, I detected p3-Alc peptides from CSF samples and plasma samples of AD patients. Our results suggest that alternative processing of multiple gamma-secretase substrates may occur in some AD patients. These finding raise the possibility that the molecular pathogenesis of AD might involve gamma-secretase dysfunction. Measurement of p3-Alc levels may be useful in selecting subjects that might benefit from patient-specific therapy aimed at modulation of gamma-secretase function.

阿尔茨海默病（Alzheimerz 'sdisease，AD）是最常见的老年性痴呆。然而，AD的发病机制仍不清楚。在本研究中，我从AD患者的脑脊液和血浆中检测了p3-Alc肽。我们的研究结果表明，多种γ-分泌酶底物的替代加工可能发生在一些AD患者。这些发现提出了AD的分子发病机制可能涉及γ-分泌酶功能障碍的可能性。测量p3-Alc水平可能有助于选择可能受益于针对γ-分泌酶功能调节的患者特异性治疗的受试者。

项目成果

Expression of novel function of Alcadein intracellular domain

Alcadein胞内结构域新功能的表达

• 发表时间: 2013
• 作者: Sobu;U.;Takei;N.;Hata;S.;Suzuki;T
• 通讯作者: T

Utility of SPM8 plus DARTEL (VSRAD) Combined with Magnetic Resonance Spectroscopy as Adjunct Techniques for Screening and Predicting Dementia due to Alzheimer's Disease in Clinical Practice

• DOI: 10.3233/jad-132786
• 发表时间: 2014-01-01
• 期刊: JOURNAL OF ALZHEIMERS DISEASE
• 影响因子: 4
• 作者: Waragai, Masaaki;Hata, Saori;Uemura, Kenichi
• 通讯作者: Uemura, Kenichi

Neuron-specific phosphorylation of APP: The roles in APP metabolism and function.

APP 的神经元特异性磷酸化：在 APP 代谢和功能中的作用。

• 发表时间: 2013
• 作者: Suzuki;T.;Matsushima;T.;Chiba;K.;Saito;Y.;Taru;H.;Hata;S.
• 通讯作者: S.

Membrane microdomain localization of APP C-terminal fragments regulated by the phosphorylation at cytoplasmic Thr668 residue

APP C 端片段的膜微域定位受细胞质 Thr668 残基磷酸化的调节

• 发表时间: 2012
• 作者: Matsushima;T.;Saito;Y.;Nishimura;M.;Kimura;N.;Hata;S. and Suzuki T
• 通讯作者: S. and Suzuki T

p3-Alc peptide in the CSF and plasma of sporadic Alzheimer's disease patients

散发性阿尔茨海默病患者脑脊液和血浆中的 p3-Alc 肽

• 发表时间: 2013
• 作者: Hata;S
• 通讯作者: S