Development of lipid bilayer membrane vesicles constructed by fat-soluble vitamin and application for cancer treatment

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In this study, we determined that cholecalciferol-derivative containing liposomes are interacted with caveolin-1 on the cell surface, and taken up into the cells via caveolae-mediated endocytosis. Moreover, we showed that cholecalciferol-derivative containing liposomes possess the cytotoxic activities, and increase the pharmaceutical activities of the other medicines such as anti-cancer agents. Since the cholecalciferol-derivatives used in this study have already been investigated the metabolic and eliminating process in the body, these components have high biocompatibility. Therefore, these results obtained from this study contribute to pharmaceutical development for the construction of effective and safe medication.