Regulatory mechanism of Reelin proteolysis

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Reelin is a secreted glycoprotein that plays essential roles in the brain formation. Reelin is specifically cleaved at two sites (N-t and C-t site). However, the mechanism and the physiological role of Reelin cleavage is largely unknown. In this study, we determined the N-t cleavage site, and found that N-t cleavage of Reelin plays critical roles in regulating the duration and range of Reelin functions. Furthermore, we identified the protease from supernatant of cultured neurons, and found that this protease is the major protease in charge of Reelin cleavage in embryonic cerebral cortex.