Mechanism of regulation of gene expression by polyamines at the level of translation depending on the interaction of polyamines with RNA

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Polyamines are essential for normal cell growth and cell viability. Polyamines exist mostly as polyamine-RNA complexes in cells. A group of genes whose expression is enhanced by polyamines at the level of translation be referred to as a "polyamine modulon".Since biofilm formation is also involved in cell viability, we looked for proteins involved in biofilm formation and cell viability whose synthesis is stimulated by polyamines at the level of translation in Escherichia coli. It was found that the synthesis of UvrY, CpxR and RRF was increased by polyamines at the level of translation. The results indicate that polyamines are necessary for both biofilm formation and cell viability.