Development of novel oral formulation expects improvement in adherence with ease of consumption

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Mixtures of 2.0% methylcellulose and 0.5% gellan gum were of suitable viscosity for easy swallowing by dysphagic patients and formed gels at temperatures between ambient and body temperature, allowing administration in liquid form and in situ gelation in the stomach. The in vitro release of acetaminophen from the methylcellulose/gellan gum gels was diffusion-controlled at pH 1.2 and pH 6.8. Plasma levels of acetaminophen measured after oral administration of the methylcellulose/gellan gum formulation to rats showed more sustainable release compared to that from methylcellulose and gellan gum solutions and from an aqueous solution of acetaminophen.