Role of p62 and Nbr1 in regulation of food intake regulation

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Though Nbr1 is known to have similar domain structure as p62, the physiological function has been uncovered. In this study, we aimed to examine the Nbr1 function. We used WT and p62-KO mice to establish WT, p62-KO, WT:Nbr2-KD, p62-KO:Nbr1KD MEFs (mouse embryonic fibroblast). We found the cell growth ratio in WT:Nbr1-KD cells are significantly slower than the other cells. Because total- and phosphorylated-p38 levels were decreased, we speculated Nbr1 has a role to regulate p38 protein level, and Nbr1 deficiency results in the decrease in cell growth ratio.