Estrogens in male breast carcinoma

雌激素在男性乳腺癌中的作用

• 批准号: 24790343
• 负责人: TAKAGI Kiyoshi
• 金额: $ 2.75万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790343/
• 关键词: 男子乳癌; エストロゲン

We examined intratumoral estrogen concentrayion, estrogen receptor and its responsive genes in male breast carcinomas in order to clarify estrogen action in male breast carcinomas.Tissue estradiol level was markedly higher in male breast carcinoma tissues, and estrogen producing enzymes were significantly detected in male breast carcinoma tissues. All cases examined in this study were positive for estrogen receptor (ER), and significant association was detected between ER and progesterone receptor. Microarray analysis did demonstrate that expression profiles of estrogen responsive genes are markedly different between male and female breast carcinomas.Therfefore, it was suggested that estrogens were loccally produced in male breast carcinoma tissues as well as female ones, while its action was quite different between male and female breast carcinomas.

为了探讨雌激素在男性乳腺癌中的作用，我们对男性乳腺癌组织中雌激素浓度、雌激素受体及其反应基因进行了检测，发现男性乳腺癌组织中雌二醇水平明显升高，雌激素产生酶在男性乳腺癌组织中明显表达。本研究中所检查的所有病例均为雌激素受体（ER）阳性，并且检测到ER与孕激素受体之间的显著相关性。基因芯片分析显示雌激素反应基因在男性和女性乳腺癌组织中的表达谱存在明显差异，提示雌激素在男性乳腺癌组织中的表达与女性乳腺癌组织中的表达相似，但雌激素在男性和女性乳腺癌组织中的作用存在明显差异。

项目成果

乳腺腫瘍学

乳腺肿瘤学

• 发表时间: 2012
• 作者: 田中俊裕;田村和夫;田中 俊裕
• 通讯作者: 田中 俊裕

Immunolocalization of ARHGAP15 in human breast carcinoma

ARHGAP15 在人乳腺癌中的免疫定位

• 发表时间: 2013
• 作者: Kiyoshi Takagi;Yasuhiro Miki;Yoshiaki Onodera;Yasuhiro Nakamura;Takanori Ishida;Hironobu Sasano and Takashi Suzuki
• 通讯作者: Hironobu Sasano and Takashi Suzuki

ARHGAP15 in human breast carcinoma: potent favorable prognostic factor induced by androgen

人乳腺癌中的 ARHGAP15：雄激素诱导的有效有利预后因素

• 发表时间: 2012
• 作者: Kiyoshi Takagi;Yasuhiro Miki;Yoshiaki Onodera;Yasuhiro Nakamura;Takanori Ishida;Hironobu Sasano;Takashi Suzuki
• 通讯作者: Takashi Suzuki

Immunolocalization of ARHGAP15 in human breast carcinoma 2013

ARHGAP15 在人乳腺癌中的免疫定位 2013

• 发表时间: 2013
• 作者: 1.Kiyoshi Takagi;Yasuhiro Miki;Yoshiaki Onodera;Yasuhiro Nakamura;Takanori Ishida;Hironobu Sasano;Takashi Suzuki
• 通讯作者: Takashi Suzuki

Expression of ARHGAP15 in human breast carcinoma (2012)

ARHGAP15 在人乳腺癌中的表达 (2012)

• 发表时间: 2012
• 作者: 2.Kiyoshi Takagi;Yasuhiro Miki;Yoshiaki Onodera;Yasuhiro Nakamura;Takanori Ishida;Hironobu Sasano;Takashi Suzuki
• 通讯作者: Takashi Suzuki