Pathological significans of CD169-positive macrophages in colorectal cancer patients

之前的CD169研究主要是在啮齿动物身上进行的；只有少数研究描述了CD169在人类中的表达。为探讨CD169在人类疾病中的作用，本研究以结直肠癌患者区域淋巴结(RLN)中CD169窦巨噬细胞为研究对象。我们检测了CD169在结直肠癌区域淋巴结(RLN)中的表达及其与总生存期的关系。对83例大肠癌患者进行临床病理分析，采用免疫组织化学方法检测石蜡包埋标本中巨噬细胞CD169的表达。我们发现高密度的CD169巨噬细胞与较长的总生存期显著相关。我们还发现CD169巨噬细胞的密度与CD8细胞毒性T细胞在肿瘤组织中的数量呈正相关。这些数据表明，RLN中的CD169巨噬细胞促进CD8T细胞介导的抗肿瘤免疫，并与结直肠癌患者较好的预后有关。

Previous CD169 studies were mainly performed with rodents; only a few studies described CD169 expression in humans. In this study, to examine the role of CD169 in human diseases, we focused on CD169+ sinus macrophages in regional lymph nodes (RLNs) of patients with colorectal carcinoma (CRC). We examined the expression of CD169 in regional lymph nodes (RLNs) and their relations with overall survival in CRC. In a clinicopathological analysis on 83 CRC patients, paraffin-embedded specimens were evaluated for CD169 expression of RLN macrophages by immunohistochemistry. We found a high density of CD169+ macrophages was significantly associated with longer overall survival. We also found that the density of CD169+ macrophages had a positive correlation with the number of CD8+ cytotoxic T cells infiltrating tumor tissues. These data suggest that CD169+ macrophages in RLNs promote CD8+ T-cell-mediated anti-tumor immunity and are associated with a better prognosis for CRC patients.