Proteomic analysis of human bile from chronic cholecystitis and gallbladder cancer

慢性胆囊炎和胆囊癌人胆汁的蛋白质组学分析

• 批准号: 24790359
• 负责人: YANAGISAWA Nobuyuki
• 金额: $ 2.41万
• 依托单位: Kitasato University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790359/
• 关键词: 慢性胆嚢炎; プロテオーム; 胆嚢発癌; 胆嚢癌

The bile and tissue samples including 160 cases of chronic cholecystitis, 33 cases of bile duct carcinomas, 7 cases of gallbladder carcinomas, 2 cases of pancreaticobiliary malformations and 4 cases of gallbladder adenomas were collected. Using LC-MS analysis, 8 proteins were detected only in gallbladder cancer, and 11 proteins were not detected in gallbladder cancer.

收集慢性胆囊炎160例、胆管癌33例、胆囊癌7例、胰胆管畸形2例、胆囊腺瘤4例等胆汁及组织标本。LC-MS分析发现，8种蛋白仅在胆囊癌中检测到，11种蛋白未在胆囊癌中检测到。