Endothalial cell-derived IL-7 controls B cell development and peripheral T cell maintenance

IL-7是淋巴细胞发育、增殖和存活所必需的细胞因子。然而，表达IL-7的细胞的确切分布和局部功能在很大程度上尚不清楚。本研究旨在阐明淋巴管内皮细胞和骨髓内皮细胞产生的IL-7对外周T细胞和骨髓B细胞的影响。通过使用内皮细胞特异性IL-7缺失的小鼠，我发现内皮细胞来源的IL-7控制着外周T细胞的迁移和骨髓B细胞的发育。

IL-7 is an essential cytokine for the development, proliferation and survival of lymphocytes. However, the precise distribution and the local function of IL-7-expressing cells are largely unknown. In this research project, I aimed to clarify the effects of IL-7 produced by lymphatic endothelial cells and bone marrow endothelial cells on peripheral T cells and bone marrow B cells. By using endothelial cell specific IL-7 deleted mice, I found that endothelial cell-derived IL-7 controls the peripheral T cell migration and bone marrow B cell development.