The role of PI3K-Akt-mTORC1 signaling pathway on Th17 differentiation

PI3K-Akt-mTORC1信号通路在Th17分化中的作用

• 批准号: 24790479
• 负责人: NAGAI Shigenori
• 金额: $ 2.83万
• 依托单位: Tokyo Medical and Dental University (2013)Keio University (2012)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790479/
• 关键词: Th17; PI3K; mTORC1; mTORC; p70S6K; Th17分化; Akt

Th17 cell is a kind of helper T (Th) cells which causes autoimmune diseases such as rheumatoid arthritis or inflammatory bowel disease. Therefore, to clarify the molecular mechanisms of Th17 differentiation is thought to lead the effective prevention or the development of the effective therapy. In this research, we demonstrated that phosphoinositide 3-kinase (PI3K)-Akt-mTORC1 signaling pathway positively regulates Th17 differentiation.

Th17细胞是一种辅助性T（Th）细胞，可引起自身免疫性疾病，如类风湿性关节炎或炎症性肠病。因此，阐明Th17分化的分子机制被认为可以引导有效的预防或开发有效的治疗方法。在这项研究中，我们证明磷酸肌醇3激酶（PI3K）-Akt-mTORC1信号通路正向调节Th17分化。

项目成果

Cellular response of immunocyte to boron-containing apatite ceramics.

免疫细胞对含硼磷灰石陶瓷的细胞反应。

• 发表时间: 2013
• 作者: Nakamura M;Zhuang Z;Umeda R;Nagai S;Aizawa M.
• 通讯作者: Aizawa M.

PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation

PI3K-Akt-mTORC1-S6K1/2 轴控制 Th17 分化

• 发表时间: 2012
• 作者: Shigenori Nagai;Yutaka Kurebayashi;Ai Ikejiri;Masashi Ohtani;Kenji Ichiyama;Yukiko Baba;Taketo Yamada;Shohei Egami;Takayuki Hoshii;Atsushi Hirao;Satoshi Matsuda;Shigeo Koyasu
• 通讯作者: Shigeo Koyasu

A comparison of biofilm formation in various metal materials

各种金属材料生物膜形成的比较

• 发表时间: 2013
• 作者: Yoshioka K ;Ishii K;Nagai S;Kakinuma H;Kuramoto T;Sasaki A;Aizawa M;Okada Y;Koyasu S;Toyama Y;Matsumoto M
• 通讯作者: Matsumoto M

Local effects of regulatory T cells in MUC1 transgenic mice potentiate growth of MUC1 expressing tumor cells in vivo.

• DOI: 10.1371/journal.pone.0044770
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Sugiura D;Denda-Nagai K;Takashima M;Murakami R;Nagai S;Takeda K;Irimura T
• 通讯作者: Irimura T

Development of pulmonary alveolar proteinosis in PI3K deficient mice

PI3K 缺陷小鼠肺泡蛋白沉积症的发展

• 发表时间: 2013
• 作者: Akihiro Yoshizawa;Shigenori Nagai;Yukiko Baba;Tomoyasu Nishimura;Taketo Yamada;Shigeo Koyasu
• 通讯作者: Shigeo Koyasu