Supporting characters may go to the heart of amyloidogenesis: Amyloid associated protein world

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It is well known that some co-localized proteins with amyloid fibrils, which are called amyloid associated proteins, may play important roles in amyloidosis. Then, we tried to pick up the strong candidates as early diagnostic markers and/or therapeutic molecules of amyloidosis in this study. As the results of our studies, we could detect some strong candidates, such as clusterin and vitronectin. Serum clusterin levels of familial amyloidotic polyneuropathy (FAP) patients was significantly higher than that of healthy volunteers. Moreover, significant higher correlation between vitronectin and TTR deposition was observed in the cardiac tissues of FAP patients.