Supporting characters may go to the heart of amyloidogenesis: Amyloid associated protein world

淀粉样蛋白相关蛋白（amyloid associated proteins，AAP）是一类与淀粉样纤维共定位的蛋白质，在淀粉样变性中起重要作用。然后，我们试图挑选出强有力的候选者作为本研究中淀粉样变性的早期诊断标志物和/或治疗分子。我们的研究结果表明，我们可以检测到一些强有力的候选者，如clusterin和vitronectin。家族性淀粉样多发性神经病（FAP）患者血清clusterin水平显著高于健康志愿者。此外，在FAP患者的心脏组织中观察到玻连蛋白和TTR沉积之间的显著更高的相关性。

It is well known that some co-localized proteins with amyloid fibrils, which are called amyloid associated proteins, may play important roles in amyloidosis. Then, we tried to pick up the strong candidates as early diagnostic markers and/or therapeutic molecules of amyloidosis in this study. As the results of our studies, we could detect some strong candidates, such as clusterin and vitronectin. Serum clusterin levels of familial amyloidotic polyneuropathy (FAP) patients was significantly higher than that of healthy volunteers. Moreover, significant higher correlation between vitronectin and TTR deposition was observed in the cardiac tissues of FAP patients.