Antimicrobial Susceptibility and Molecular Epidemiology of Drug Resistance in S. maltophilia

嗜麦芽葡萄球菌的抗菌药物敏感性和耐药性的分子流行病学

• 批准号: 24790546
• 负责人: KANAMORI HAJIME
• 金额: $ 2.75万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790546/
• 关键词: 感染症; S. maltophilia; 薬剤感受性; Smqnr

Stenotrophomonas maltophilia infections are difficult to treat as the bacterium exhibits high-level intrinsic resistance to a variety of antimicrobial agents. Smqnr have been recently identified in S. maltophilia as a novel chromosomal quinolone resistance gene. In this study, we investigated the antimicrobial susceptibility and the prevalence of Smqnr among S. maltophilia isolates in Japan. Resistance rates to ceftazidime, levofloxacin, trimethoprim-sulfamethoxazole, and minocycline were 67%, 6%, 18%, and 0%, respectively. Smqnr was detected at high frequencies in S. maltophilia isolates (approximately 60%), and there were regional differences in Smqnr frequency. In this study, we described novel variants of Smqnr.

嗜麦芽窄养单胞菌感染很难治疗，因为这种细菌对多种抗菌剂表现出高水平的内在耐药性。Smqnr是最近在嗜麦芽链球菌中发现的一种新的喹诺酮类耐药基因。在这项研究中，我们调查了日本嗜麦芽葡萄球菌的耐药性和Smqnr的流行率。头孢他啶耐药率为67%，左氧氟沙星耐药率为6%，甲氧苄啶-磺胺甲恶唑耐药率为18%，米诺环素耐药率为0%。Smqnr在嗜麦芽葡萄球菌分离株中检出频率较高（约60%），且存在区域差异。在这项研究中，我们描述了Smqnr的新变体。

项目成果

本邦におけるStenotrophomonas maltophiliaのSmqnrに関する検討

日本嗜麦芽寡养单胞菌的监测研究

• 发表时间: 2014
• 作者: 金森肇;田内絢子;矢野寿一;遠藤史郎;小川美保;霜島正浩;賀来満夫
• 通讯作者: 賀来満夫

Lessons learned from a tuberculosis contact investigation associated with a disaster volunteer after the 2011 Great East Japan Earthquake

2011 年东日本大地震后与一名救灾志愿者相关的结核病接触者调查的经验教训

• DOI: 10.1164/rccm.201212-2150le
• 发表时间: 2013
• 期刊: Am J Respir Crit Care Med
• 作者: Kanamori H;Uchiyama B;Hirakata Y;Chiba T;Okuda M;Kaku M
• 通讯作者: Kaku M

Clinical Characteristics of Active Pulmonary Tuberculosis after the 2011 Great East Japan Earthquake

2011年东日本大地震后活动性肺结核的临床特征

• 发表时间: 2013
• 作者: Kanamori H;Aso N;Uchiyama B;Saito H;Hirakata Y;Kaku M
• 通讯作者: Kaku M

Descriptive analysis of healthcare-associated infections other than bloodstream, respiratory, urinary tract, or surgical site infections

对血液、呼吸道、泌尿道或手术部位感染以外的医疗保健相关感染的描述性分析

• DOI: 10.1086/668423
• 发表时间: 2012
• 期刊: Infect Control Hosp Epidemiol
• 作者: Kanamori H;Weber DJ;Sickbert-Bennett EE;Brown V;Kaku M;Rutala WA
• 通讯作者: Rutala WA

Role of Clinical Laboratory Test and Lessons Learned from Infection Control and Prevention in the Affected Area

临床实验室检测的作用以及受影响地区感染控制和预防的经验教训

• 发表时间: 2013
• 作者: Kanamori H;Nagasawa M;Endo S;Aoyagi T;Hatta M;Gu Y;Tokuda K;Yano H;Kaku M
• 通讯作者: Kaku M