Antimicrobial Susceptibility and Molecular Epidemiology of Drug Resistance in S. maltophilia

嗜麦芽窄养单胞菌感染很难治疗，因为这种细菌对多种抗菌剂表现出高水平的内在耐药性。Smqnr是最近在嗜麦芽链球菌中发现的一种新的喹诺酮类耐药基因。在这项研究中，我们调查了日本嗜麦芽葡萄球菌的耐药性和Smqnr的流行率。头孢他啶耐药率为67%，左氧氟沙星耐药率为6%，甲氧苄啶-磺胺甲恶唑耐药率为18%，米诺环素耐药率为0%。Smqnr在嗜麦芽葡萄球菌分离株中检出频率较高（约60%），且存在区域差异。在这项研究中，我们描述了Smqnr的新变体。

Stenotrophomonas maltophilia infections are difficult to treat as the bacterium exhibits high-level intrinsic resistance to a variety of antimicrobial agents. Smqnr have been recently identified in S. maltophilia as a novel chromosomal quinolone resistance gene. In this study, we investigated the antimicrobial susceptibility and the prevalence of Smqnr among S. maltophilia isolates in Japan. Resistance rates to ceftazidime, levofloxacin, trimethoprim-sulfamethoxazole, and minocycline were 67%, 6%, 18%, and 0%, respectively. Smqnr was detected at high frequencies in S. maltophilia isolates (approximately 60%), and there were regional differences in Smqnr frequency. In this study, we described novel variants of Smqnr.