Effects of tryptophan metabolites on IFN-induced depressive symptoms

色氨酸代谢物对干扰素诱导的抑郁症状的影响

• 批准号: 24790552
• 负责人: MURAKAMI Yuki
• 金额: $ 2.83万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790552/
• 关键词: トリプトファン代謝; 副作用; 薬物誘発性抑うつ; 発症予測; 抑うつ; IDO1

The therapy for chronic hepatitis C (HCV) using interferon is currently recommended, however, psychiatric disorders such as depression are frequent in HCV patients during the therapy. Many researchers propose indoleamine 2,3-dioxygenase (IDO) 1, which is one of first rate-limiting enzyme of the kynurenine pathway, and IDO1-mediated tryptophan (TRP) metabolites be implicated in the development of IFN-induced depression. In this study, we measured TRP and its metabolites and investigated correlations between TRP metabolites and depression induced by IFN therapy. Following IFN therapy, the concentration of serum TRP was reduced, while some TRP metabolites were increased, then returned to baseline values after the end of the therapy. The ratio of TRP and metabolites were significantly increased under the therapy, especially with depression. We speculate that the indexing, combination between some TRP metabolites, is effective in prediction of the depression induced by IFN therapy.

目前推荐使用干扰素治疗慢性丙型肝炎（HCV），但HCV患者在治疗期间经常出现精神障碍，如抑郁症。许多研究者认为犬尿氨酸途径的第一限速酶吲哚胺2，3-双加氧酶（IDO）1及其介导的色氨酸（TRP）代谢产物与IFN诱导的抑郁症的发生有关。在这项研究中，我们测量了TRP及其代谢产物，并研究了TRP代谢产物与IFN治疗诱导的抑郁症之间的相关性。IFN治疗后血清TRP浓度降低，部分TRP代谢产物升高，治疗结束后恢复至基线水平。治疗后TRP及其代谢产物的比值明显升高，尤其是抑郁症患者。我们推测，一些TRP代谢产物之间的索引组合，是有效的预测干扰素治疗引起的抑郁症。

项目成果

Remarkable role of indoleamine 2,3-dioxygenase and tryptophan metabolites in infectious disease : potential role in macrophage-mediated inflammatory diseases

吲哚胺2,3-双加氧酶和色氨酸代谢物在传染病中的显着作用：在巨噬细胞介导的炎症性疾病中的潜在作用

• 发表时间: 2013
• 期刊: Mediators Inflamm
• 作者: Murakami Y;Hoshi M;Imamura Y;Arioka Y;Yamamoto Y;Saito K
• 通讯作者: Saito K

Indole 2,3-dioxygenase 1 modulates the immuneresponse; the new targets of this drug.

吲哚 2,3-双加氧酶 1 调节免疫反应；

• 发表时间: 2013
• 期刊: Nihon Yakurigaku Zasshi
• 作者: Yamamoto Y;Murakami Y;Hoshi M;Saito K
• 通讯作者: Saito K

インターフェロン誘発性抑うつ発症時のトリプトファン代謝産物動態解析

干扰素诱发抑郁症发病过程中色氨酸代谢物的动态分析

• 发表时间: 2013
• 作者: 村上由希;石橋貴明;安藤量基;富田栄一;竹村正男;山本康子;齋藤邦明
• 通讯作者: 齋藤邦明

Matrix Metalloproteinase-9 Triggers the Gap Junction Impairment and Somatosensory Neuronal Dysfunction in Septic Encephalopathy

• DOI: 10.4172/2167-0501.1000108
• 发表时间: 2013
• 期刊: Biochemical Pharmacology
• 影响因子: 5.8
• 作者: Huan Wang;Y. Imamura;N. Matsumoto;Nao Yoshikawa;Junichiro Nakagawa;K. Yamakawa;Tomoki Yamada;Yuki Murakami;S. Mitani;Takashi Jin;H. Ogura;T. Shimazu;A. Seiyama

Species difference in Tryptophan metabolism.

色氨酸代谢的物种差异。

• 发表时间: 2012
• 作者: 村上由希，石橋貴明;安藤量基;富田栄一;竹村正男;山本康子;齋藤邦明;Murakami Y
• 通讯作者: Murakami Y