Whether or not exercise in the juvenile period prevents depression-like behaviour in the maturation period via epigenetic gene regulation

青少年时期的锻炼是否可以通过表观遗传基因调控来预防成熟期的抑郁样行为

• 批准号: 24700714
• 负责人: NAKAJIMA SANAE
• 金额: $ 2.83万
• 依托单位: Kyoritsu Women's Junior College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24700714/
• 关键词: 運動; ストレス; 成長期; 心理的ストレス; 成熟期

The antidepressant effect of regular exercise in the juvenile period were examined with the mice had not done any exercises during the growing season and the mice had done regular exercise in the juvenile period, by giving them a psychological stress during the period of maturity. From the result of behavioral experiments, which was to determine the behavioral changes during depression and acceptability experiments, the possibility of regular exercise in the juvenile period that can ease behavioral changes during depression was indicated. However, no significant change in neurogenesis of the hippocampal was observed from each group. It requires more time to establish the methodology, the research was not at the stage of comparative investigation whether there was any epigenetic mutation or not.

在发育成熟期给小鼠施加心理压力，观察幼年期定期运动对生长季不运动和幼年期定期运动小鼠的抗抑郁作用。从确定抑郁期行为变化的行为实验和可接受性实验的结果来看，青少年期定期运动可以缓解抑郁期行为变化的可能性。然而，各组海马神经发生未见明显变化。方法的建立需要更多的时间，研究还没有处于是否存在表观遗传突变的比较调查阶段。