Transcriptome analysis of the effects of short-term dietary magnesium deficiency on the hepatic nutrition metabolism in rats.

我们对短期(2周或3天)缺乏镁饮食的大鼠的肝脏基因表达进行了全球分析，结果是肝脏能量代谢或多或少发生了变化。这些变化与长期(4周)喂食相同缺镁饮食的大鼠相似。因此，长期喂养缺镁饮食的大鼠肝脏能量代谢的整体变化很可能已经在短期内诱导。然而，低镁饲料喂养大鼠的某些血清生化指标和部分肝脏基因表达的变化在两个给药时期是不同的。我们还表征了镁缺乏给药期差异的时间因素。

We performed a global analysis of hepatic gene expression in rats fed a magnesium (Mg)-deficient diet for a shorter term (2 weeks or 3 days), with the result that hepatic energy metabolism was changed to a greater or lesser extend. These changes were generally similar to those in rats fed the same Mg-deficient diet for a longer term (4 weeks). Thus it is likely that overall changes in hepatic energy metabolism in rats fed the Mg-deficient diet for the longer term are already induced shortly. However, changes in some serum biochemical parameters and some hepatic gene expression in rat fed the Mg-deficient diet were different between the two administration periods. We also characterized temporal factors specific to the difference in the Mg-deficient administration periods.