Regulation of EGF signaling transduction in breast cancer-initiating cells and their niches

乳腺癌起始细胞及其微环境中 EGF 信号转导的调节

• 批准号: 24700968
• 负责人: MIZUTANI ANNA
• 金额: $ 2.83万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24700968/
• 关键词: がん幹細胞; 乳がん; 癌幹細胞

Recently cancer-initiating cells have been considered to be important targets in chemotherapy. Our data using breast cancer cell lines shows transforming growth factor (TGF)-beta signaling is involved in cancer-initiating like cell maintenance in addition to epidermal growth factor (EGF) and fibroblast growth factor (FGF) signaling. We previously showed that epithelial splicing regulatory protein (ESRP) was transcriptionally down-regulated by TGF-beta. ESRPs are involved in mRNA splicing widely. We investigated the regulatory mechanisms of ESRPs. Here we obtained the data which could be a clue to understand the regulatory mechanism of ESRPs.

最近，癌症起始细胞被认为是化疗的重要靶点。我们使用乳腺癌细胞系的数据显示，除了表皮生长因子（EGF）和成纤维细胞生长因子（FGF）信号传导之外，转化生长因子（TGF）-β信号传导还参与癌症起始样细胞的维持。我们之前表明，上皮剪接调节蛋白（ESRP）在转录上被 TGF-β 下调。 ESRP 广泛参与 mRNA 剪接。我们研究了 ESRP 的监管机制。这里我们获得的数据可以为理解ESRP的调控机制提供线索。

项目成果

Regulatory mechanism of ESRP1 and ESRP2 proteins

ESRP1和ESRP2蛋白的调控机制

• 发表时间: 2013
• 作者: 水谷アンナ;鯉沼代造;宮園浩平
• 通讯作者: 宮園浩平