Bionic Transdermal Patch

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We report here a transdermal biofuel cell patch that is composed of bioanode fabrics for fructose oxidation, hydrogel tanks containing fructose fuel and chemical compounds (Rhodamine B and ascorbyl glucoside (AG)), O2-diffusion biocathode fabrics, and an ion-isolating hydrophobic flame. When the patch is mounted on the mammalian skin, the patch generate the ionic current of ca.140 microampere cm-2 between the anode and the cathode across the skin. This ion current could be controlled by setting up the external resistance. The applied current induced a water flow of ca. 7.7 microliter cm-2 for 1 h at small current of 5 microampere cm-2 toward the cathode, and then assisted a chemical administration into the skin (ex. AG delivery of 20 microgram cm-2 within the epidermis and 2.5 microgram cm-2 within the dermis) at the anodic side.