Development of synthetic small molecules that control the lipid biosynthesis

设计并合成了基于“法图他汀”结构的各种小分子，该“法图他汀”是本研究小组鉴定的抑制脂质生物合成途径的合成分子。这些合成的分子对脂质生物合成的重要蛋白质的抑制作用通过基于细胞的报告分析来评估。结果，获得了一种新的小分子，其对脂质生物合成途径显示出比先前的小分子更有效的抑制作用。现在，它在细胞中的详细功能进行了研究。

Various small molecules based on the structure of "fatostatin", which was a synthetic molecule identified by our research group that inhibits a lipid biosynthetic pathway, were designed and synthesized. The inhibitory effects of these synthesized molecules on the important protein for the lipid biosynthesis were evaluated by the cell-based reporter assay. As a result, a new small molecule that shows more potent inhibitory effects on the lipid biosynthesis pathway than previous ones was obtained. Now, its detail function in cells are investigated.