Identification of causative genes for hereditary cancer by genome analyses of familial cancer cases and its application

家族性癌症病例基因组分析识别遗传性癌症致病基因及其应用

• 批准号: 25430180
• 负责人: Kukita Yoji
• 金额: $ 3.33万
• 依托单位: Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25430180/
• 关键词: 疾患関連遺伝子; 癌

项目成果

Dynamics of circulating tumor DNA represented by the activating and resistant mutations in epidermal growth factor receptor tyrosine kinase inhibitor treatment.

表皮生长因子受体酪氨酸激酶抑制剂治疗中的激活突变和耐药突变代表循环肿瘤 DNA 的动态。

• DOI: 10.1111/cas.12860
• 发表时间: 2016-03
• 期刊: Cancer science
• 影响因子: 5.7
• 作者: Uchida J;Imamura F;Kukita Y;Oba S;Kumagai T;Nishino K;Inoue T;Kimura M;Kato K
• 通讯作者: Kato K

High-fidelity target sequencing of individual molecules identified using barcode sequences: de novo detection and absolute quantitation of mutations in plasma cell-free DNA from cancer patients.

• DOI: 10.1093/dnares/dsv010
• 发表时间: 2015-08
• 期刊: DNA research : an international journal for rapid publication of reports on genes and genomes
• 作者: Kukita Y;Matoba R;Uchida J;Hamakawa T;Doki Y;Imamura F;Kato K
• 通讯作者: Kato K

Quantitative identification of mutant alleles derived from lung cancer in plasma cell-free DNA via anomaly detection using deep sequencing data.

• DOI: 10.1371/journal.pone.0081468
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Kukita Y;Uchida J;Oba S;Nishino K;Kumagai T;Taniguchi K;Okuyama T;Imamura F;Kato K
• 通讯作者: Kato K

Non-overlapping integrated reads sequencing system (NOIR SeqS) for de novo detection and absolute quantitation of mutations in circulating tumor DNA.

非重叠集成读取测序系统 (NOIR SeqS)，用于循环肿瘤 DNA 突变的从头检测和绝对定量。

• 发表时间: 2016
• 作者: Kukita Y;Matoba R;Uchida J;Takada R;Hamakawa T;Doki Y;Imamura F;Katayama K;Kato K
• 通讯作者: Kato K

Detection of mutations in plasma DNA from cancer patients by high-fidelity target sequencing of individual molecules.

通过对单个分子进行高保真目标测序来检测癌症患者血浆 DNA 中的突变。

• 发表时间: 2015
• 作者: 久木田洋児;的場亮;内田純二;浜川卓也;土岐祐一郎;今村文生;加藤菊也
• 通讯作者: 加藤菊也