Base construction for the development of therapeutic strategies for targeting cell adhesion molecules in atherosclerosis

动脉粥样硬化靶向细胞粘附分子治疗策略开发的基础构建

• 批准号: 25461128
• 负责人: Rikitake Yoshiyuki
• 金额: $ 3.24万
• 依托单位: Kobe Pharmaceutical University (2015)Kobe University (2013-2014)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461128/
• 关键词: 細胞接着分子; 血管内皮細胞; シグナル伝達; 内膜肥厚; 血管炎症; 糖鎖修飾; 接触阻害; 炎症; 血管平滑筋細胞; 運動; 増殖

项目成果

Regulation of Vascular Endothelial Cell Functions by Necl-4 through the PTPN13-ROCK Pathway

Necl-4 通过 PTPN13-ROCK 通路调节血管内皮细胞功能

• 作者: Shota Yamana;Mitsuo Kinugasa;Yuya Terao;Ken-ichi Hirata;Yoshiyuki Rikitake
• 通讯作者: Yoshiyuki Rikitake

Nectin and heterotypic cell－cell adhesion

Nectin 和异型细胞间粘附

• 发表时间: 2014
• 作者: 岡本貴行;島岡要;Yoshiyuki Rikitake
• 通讯作者: Yoshiyuki Rikitake

Expression and pro-inflammatory functions of FAM5C, a genetic risk factor for acute mayocardial infarction, in vascular endothelial cells

FAM5C（急性心肌梗死的遗传危险因素）在血管内皮细胞中的表达和促炎功能

• 作者: Mitsuo Kinugasa;Yoshiyuki Rikitake;Seimi Satomi-Kobayashi;Kinta Hatakeyama;Shota Yamana;Fumie Kureha;Junya Satoh;Yujiro Asada;Ken-ichi Hirata
• 通讯作者: Ken-ichi Hirata

Family with sequence similarity 5, member C (FAM5C) increases leukocyte adhesion molecules in vascular endothelial cells: implication in vascular inflammation.

• DOI: 10.1371/journal.pone.0107236
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Sato J;Kinugasa M;Satomi-Kobayashi S;Hatakeyama K;Knox AJ;Asada Y;Wierman ME;Hirata K;Rikitake Y
• 通讯作者: Rikitake Y

A Dual Role of Cell Adhesion Molecule Necl-4 in Endothelial Cells: Promotion of Migration Under Sparse Conditions and Inhibition of Proliferation Under Confluent Conditions

细胞粘附分子Necl-4在内皮细胞中的双重作用：稀疏条件下促进迁移和汇合条件下抑制增殖

• 发表时间: 2014
• 作者: Shota Yamana;Amina Tokiyama;Yuya Terao;Ken-ichi Hirata;Yoshiyuki Rikitake
• 通讯作者: Yoshiyuki Rikitake