Development of novel microRNA-based therapy against KRAS/BRAF-mutant colorectal cancer

开发基于 microRNA 的新型 KRAS/BRAF 突变结直肠癌疗法

• 批准号: 25462057
• 负责人: TAZAWA HIROSHI
• 金额: $ 3.24万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25462057/
• 关键词: マイクロRNA; 大腸癌; KRAS; BRAF; EGFR

项目成果

Color-coding cancer and stromal cells with genetic reporters in a patient-derived orthotopic xenograft (PDOX) model of pancreatic cancer enhances fluorescence-guided surgery.

• DOI: 10.1038/cgt.2015.26
• 发表时间: 2015-07
• 期刊: Cancer gene therapy
• 影响因子: 6.4
• 作者: Yano S;Hiroshima Y;Maawy A;Kishimoto H;Suetsugu A;Miwa S;Toneri M;Yamamoto M;Katz MH;Fleming JB;Urata Y;Tazawa H;Kagawa S;Bouvet M;Fujiwara T;Hoffman RM
• 通讯作者: Hoffman RM

Cytotoxic effect of photosensitive fluorescent protein KillerRed-expressing adenovirus against human cancer cells

表达光敏荧光蛋白 KillerRed 的腺病毒对人癌细胞的细胞毒作用

• 发表时间: 2013
• 作者: Takehara K;Tazawa H;Hashimoto Y;Kishimoto H;Narii N;Mizuguchi H;Fujiwara T
• 通讯作者: Fujiwara T

Genetic and epigenetic alterations of netrin-1 receptors in gastric cancer with chromosomal instability.

• DOI: 10.1186/s13148-015-0096-y
• 发表时间: 2015
• 期刊: Clinical epigenetics
• 影响因子: 5.7
• 作者: Toda K;Nagasaka T;Umeda Y;Tanaka T;Kawai T;Fuji T;Taniguchi F;Yasui K;Kubota N;Takehara Y;Tazawa H;Kagawa S;Sun DS;Nishida N;Goel A;Fujiwara T
• 通讯作者: Fujiwara T

Telomerase-specific oncolytic adenovirus OBP-301 kills quiescent peritonially disseminated cancer cells

端粒酶特异性溶瘤腺病毒 OBP-301 杀死静止腹膜播散的癌细胞

• 发表时间: 2013
• 作者: Yano S;Tazawa H;Kishimoto H;Fujiwara T;Hoffman RM
• 通讯作者: Hoffman RM

Tumor Suppressor Genes: Functions, Regulation and Health Effects

肿瘤抑制基因：功能、调节和健康影响

• 发表时间: 2013
• 作者: Tazawa H;Kagawa S;Fujiwara T
• 通讯作者: Fujiwara T