Study on effect of electrostatic interactions on stability of electron transfer complexes and amyloid fibrils

静电相互作用对电子转移复合物和淀粉样原纤维稳定性影响的研究

• 批准号: 25870407
• 负责人: LEE Young-Ho
• 金额: $ 2.83万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25870407/
• 关键词: Amyloid fibril; Binding thermodynamics; Calorimetry; Electron transfer; Electrostatics; Enzyme activity; Interprotein interaction; Protein misfolding; Charge interaction; Enthalpy and entropy; Hydrophobic effect; Intermolecular force; Protein

项目成果

Heat-induced Irreversible Denaturation of the Camelid Single Domain VHH Antibody Is Governed by Chemical Modifications

• DOI: 10.1074/jbc.m113.534222
• 发表时间: 2014-05-30
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Akazawa-Ogawa, Yoko;Takashima, Mizuki;Hagihara, Yoshihisa
• 通讯作者: Hagihara, Yoshihisa

Finely-tuned intermolecular interactions for protein function

精细调节蛋白质功能的分子间相互作用

• 发表时间: 2014
• 作者: Yoko Kimata-Ariga;Hisako Kubota-Kawai;Young-Ho Lee;Norifumi Muraki;Takahisa Ikegami;Genji Kurisu;Toshiharu Hase;Young-Ho Lee
• 通讯作者: Young-Ho Lee

Concentration-dependent oligomerization of cross-linked complexes between ferredoxin and ferredoxin-NADP+ reductase

铁氧还蛋白和铁氧还蛋白-NADP还原酶之间交联复合物的浓度依赖性寡聚化

• DOI: 10.1016/j.bbrc.2013.04.033
• 发表时间: 2013
• 期刊: Biochemical and Biophysical Research Communications
• 影响因子: 3.1
• 作者: Yoko Kimata-Ariga;Hisako Kubota-Kawai;Young-Ho Lee;Norifumi Muraki;Takahisa Ikegami;Genji Kurisu;Toshiharu Hase
• 通讯作者: Toshiharu Hase

Remaining structures at the N- and C-terminal regions of alpha-synuclein accurately elucidated by amide-proton exchange NMR with fitting

• DOI: 10.1016/j.febslet.2013.09.039
• 发表时间: 2013-11-15
• 期刊: FEBS LETTERS
• 影响因子: 3.5
• 作者: Okazaki, Honoka;Ohori, Yuka;Nishimura, Chiaki
• 通讯作者: Nishimura, Chiaki

Cold-denaturation of amyloid fibrils of alpha-synuclein based on a main-chain dominated architecture

基于主链主导结构的α-突触核蛋白淀粉样原纤维的冷变性

• 发表时间: 2013
• 作者: Yoko Kimata-Ariga;Hisako Kubota-Kawai;Young-Ho Lee;Norifumi Muraki;Takahisa Ikegami;Genji Kurisu;Toshiharu Hase;Young-Ho Lee;李 映昊(a)
• 通讯作者: 李 映昊(a)