Visualization of signaling mechanism underlying pre- and postsynaptic functional modification

突触前和突触后功能修饰基础信号机制的可视化

• 批准号: 25870895
• 负责人: KAWAGUCHI Shin-ya
• 金额: $ 2.75万
• 依托单位: Doshisha University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25870895/
• 关键词: シナプス; シナプス可塑性; 小脳; プルキンエ細胞; 軸索; 可視化; 培養; シナプス前部; イメージング; 短期シナプス可塑性; 軸索終末

项目成果

Gating of long-term depression by Ca2+/calmodulin-dependent protein kinase II through enhanced cGMP signalling in cerebellar Purkinje cells.

Ca2/钙调蛋白依赖性蛋白激酶 II 通过增强小脑浦肯野细胞中的 cGMP 信号传导来门控长期抑郁。

• DOI: 10.1113/jphysiol.2012.245787
• 发表时间: 2013
• 期刊: J. Physiol.
• 作者: S. Kawaguchi;T. Hirano
• 通讯作者: T. Hirano

Model prediction and experimental validation of mechanisms regulating synaptic plasticity in the cerebellum

小脑突触可塑性调节机制的模型预测和实验验证

• 发表时间: 2014
• 作者: F. Diaz;T. Sakaba;S. Kawaguchi;S. Kawaguchi
• 通讯作者: S. Kawaguchi

Ca2+ current facilitation underlies short-term facilitation at inhibitory synapses between Purkinje cells.

Ca2 电流促进是浦肯野细胞之间抑制性突触短期促进的基础。

• 发表时间: 2015
• 作者: F. Diaz;T. Sakaba;S. Kawaguchi
• 通讯作者: S. Kawaguchi

Contribution of Postsynaptic GluD2 to Presynaptic R-type Ca2+ Channel Function, Glutamate Release and Long-term Potentiation at Parallel Fiber to Purkinje Cell Synapses

• DOI: 10.1007/s12311-013-0474-y
• 发表时间: 2013-04
• 期刊: The Cerebellum
• 作者: Manami Yamashita;Shin-ya Kawaguchi;T. Hirano

Long-term Potentiation of Inhibitory Synaptic Transmission onto Cerebellar Purkinje Neurons Contributes to Adaptation of Vestibulo-Ocular Reflex

• DOI: 10.1523/jneurosci.0793-13.2013
• 发表时间: 2013-10
• 期刊: The Journal of Neuroscience
• 作者: Shinsuke Tanaka;Shin-ya Kawaguchi;G. Shioi;T. Hirano