Identification of key genes that is correlated with long-term maintenance of cytotoxic activity in WT1 specific cytotoxic T lymphocytes

鉴定与 WT1 特异性细胞毒性 T 淋巴细胞的细胞毒活性长期维持相关的关键基因

• 批准号: 25830116
• 负责人: MORIMOTO Soyoko
• 金额: $ 2.75万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25830116/
• 关键词: WT1特異的CTL; single cell定量PCR; WT1; memory

项目成果

Wilms tumor gene (WT1) peptide-based cancer vaccine combined with gemcitabine for patients with advanced pancreatic cancer.

• DOI: 10.1097/cji.0000000000000020
• 发表时间: 2014-02
• 期刊: Journal of immunotherapy (Hagerstown, Md. : 1997)
• 作者: Nishida S;Koido S;Takeda Y;Homma S;Komita H;Takahara A;Morita S;Ito T;Morimoto S;Hara K;Tsuboi A;Oka Y;Yanagisawa S;Toyama Y;Ikegami M;Kitagawa T;Eguchi H;Wada H;Nagano H;Nakata J;Nakae Y;Hosen N;Oji Y;Tanaka T;Kawase I;Kumanogoh A;Sakamoto J;Doki Y;Mori M;Ohkusa T;Tajiri H;Sugiyama H
• 通讯作者: Sugiyama H

Two distinct effector memory cell populations of WT1 (Wilms' tumor gene 1)-specific cytotoxic T lymphocytes in acute myeloid leukemia patients

急性髓系白血病患者中 WT1（维尔姆斯肿瘤基因 1）特异性细胞毒性 T 淋巴细胞的两个不同的效应记忆细胞群

• DOI: 10.1007/s00262-015-1683-7
• 发表时间: 2015
• 期刊: Cancer Immunology, Immunotherapy
• 作者: Nakae Y.;Oka Y.;Fujiki F.;Morimoto S.;Kamiya T.;Takashima S.;Nakata J.;Nishida S.;Nakajima H.;Hosen N.;Tsuboi A;Kyo T.;Oji Y.;Mizuguchi K.;Kumanogoh A.;Sugiyama H.
• 通讯作者: Sugiyama H.

Response assessments in WT1 peptide vaccination an long term results of combined temozolomide therapy

WT1 肽疫苗接种的反应评估和联合替莫唑胺治疗的长期结果

• 发表时间: 2014
• 作者: Naoya Hashimoto;Akihiro Tsuboi;Yasuyoshi Chiba;Yoshihiro Oka;Soyoko Morimoto;Hiroko Nakajima;Sumiyuki Nishida;Naoki Hosen;Naoki Kagawa;Yusuke Oji;Toshiki Yoshimine;Haruo Sugiyama
• 通讯作者: Haruo Sugiyama

Wilms’ tumor gene 1 (WT1) peptide-based cancer vaccine combined with gemcitabine for patients with advanced pancreatic cancer

Wilms 肿瘤基因 1 (WT1) 肽癌症疫苗联合吉西他滨治疗晚期胰腺癌患者

• 发表时间: 2014
• 作者: 和田はるか;細井亮宏;垣見和宏;清野研一郎;Shigeo Koido et al.
• 通讯作者: Shigeo Koido et al.

HLA class II 拘束性WT1特異的T cell Receptor遺伝子導入によるヘルパー活性とキラー活性を有するCD+4 T細胞の作製

通过 HLA II 类限制性 WT1 特异性 T 细胞受体基因转移产生具有辅助和杀伤活性的 CD+4 T 细胞

• 发表时间: 2013
• 作者: Shigeo Koido;Sumiyuki Nishida;Sadamu Homma;Yutaka Takeda;Hideo Komita;Satoshi Morita;Toshinori Ito;Soyoko Morimoto;Yoshihiro Oka;Satoru Yanagisawa;Yoichi Toyama;Masahiro Ikegami;Hiroaki Nagano;Toshifumi Ohkusa;Hisao Tajiri;Haruo Sugiyama;藤木文博，林ユウ宏，勝原晶子，岡芳弘，坪井昭博，青山奈央，谷井里江，中島博子，森本創世子，保仙直毅，尾路祐介，熊ノ郷淳，杉山治夫
• 通讯作者: 藤木文博，林ユウ宏，勝原晶子，岡芳弘，坪井昭博，青山奈央，谷井里江，中島博子，森本創世子，保仙直毅，尾路祐介，熊ノ郷淳，杉山治夫