Investigation on molecular mechanism for progression of pulmonary alveolar proteinosis by next generation sequencing.

二代测序研究肺泡蛋白沉积症进展的分子机制。

• 批准号: 15H04829
• 负责人: Nakata Koh
• 金额: $ 11.48万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04829/
• 关键词: 肺胞蛋白症; 分子細胞呼吸器学

项目成果

Assay system development to measure the concentration of sargramostim with high specificity in patients with autoimmune pulmonary alveolar proteinosis after single-dose inhalation

开发测定系统以高特异性测量单剂量吸入后自身免疫性肺泡蛋白沉积症患者沙格司亭的浓度

• DOI: 10.1016/j.jim.2018.05.012
• 发表时间: 2018
• 期刊: Journal of Immunological Methods
• 影响因子: 2.2
• 作者: Nakano Ryu;Nakagaki Kazuhide;Itoh Yuko;Seino Utako;Ueda Takahiro;Tazawa Ryushi;Kitamura Nobutaka;Tanaka Takahiro;Nakata Koh
• 通讯作者: Nakata Koh

GATA binding protein 2 (GATA2) mutation identified in a Japanese patient with adult-onset pulmonary alveolar proteinosis

在一名成人发病的肺泡蛋白沉积症日本患者中发现 GATA 结合蛋白 2 (GATA2) 突变

• 发表时间: 2016
• 作者: R. Tazawa;R. Sato;M. Ito;A. P. Hsu;Y. Ito;S. Akagawa;J. Tohyama;A. Hebisawa;K. Ohta;K. Nakata
• 通讯作者: K. Nakata

The Analysis Of Alveolar Macrophage Form On BALF Specimens In Secondary Pulmonary Alveolar Proteinosis

继发性肺泡蛋白沉积症 BALF 标本肺泡巨噬细胞形态分析

• 发表时间: 2015
• 作者: Haruyuki Ishii;Ryushi Tazawa;Yoshikazu Inoue;Takeshi Saraya;Takashi Koide;Tomohiro Handa;Masato Morita;Shigeki Yamamoto;Yoshinori Tanino;Shinya Ohkouchi;Keisuke Tomii;Koh Nakata
• 通讯作者: Koh Nakata

Strategy for Development of New Drug against Intractable Rare Diseases

罕见病疑难杂症新药开发策略

• 发表时间: 2016
• 作者: Yagi Noriaki;Itoh Hideki;Hisamatsu Takashi;Tomita Yukinori;Kimura Hiromi;Fujii Yusuke;Makiyama Takeru;Horie Minoru;Ohno Seiko;中田 光
• 通讯作者: 中田 光

Sequential GM-CSF Inhalation Reinforces the Efficiency of Whole Lung Lavage to Treat Auto-Immune Pulmonary Alveolar Proteinosis

序贯 GM-CSF 吸入增强全肺灌洗治疗自身免疫性肺泡蛋白沉积症的效率

• 发表时间: 2015
• 作者: Shinya Ohkouchi;Keiichi Akasaka;Toshio Ichiwata;Masakazu Ichinose;Hajime Kurosawa;Koh Nakata;Ryushi Tazawa
• 通讯作者: Ryushi Tazawa